Publications
Publications
2021
Alkhashrom S. , Kicuntod J. , Häge S. , Schweininger J. , Muller Y. , Lischka P. , Marschall M. , Eichler J. :Exploring the Human Cytomegalovirus Core Nuclear Egress Complex as a Novel Antiviral Target: A New Type of Small Molecule Inhibitors Viruses 13 2021 )ISSN: 1999-4915 10.3390/v13030471 Download Grau F. , Burkovski A. , Muller Y. :Crystal structures of adenylylated and unadenylylated PII protein GlnK from Corynebacterium glutamicum Acta Crystallographica Section D : Structural Biology 77 2021 ), S. 325-335 ISSN: 2059-7983 10.1107/S2059798321000735 Download
2020
Grau F. , Jaeger J. , Groher F. , Suess B. , Muller Y. :The complex formed between a synthetic RNA aptamer and the transcription repressor TetR is a structural and functional twin of the operator DNA-TetR regulator complex Nucleic Acids Research 48 2020 ), S. 3366-3378 ISSN: 0305-1048 10.1093/nar/gkaa083 Download Grosche L. , Knippertz I. , König C. , Royzman D. , Wild A. , Zinser E. , Sticht H. , Muller Y. , Steinkasserer A. , Lechmann M. :The CD83 Molecule – An Important Immune Checkpoint Frontiers in Immunology 11 2020 ), Art.Nr.: 721 ISSN: 1664-3224 10.3389/fimmu.2020.00721 Download Klingl S. , Kordes S. , Schmid B. , Gerlach R. , Hensel M. , Muller Y. :Recombinant protein production and purification of SiiD, SiiE and SiiF - Components of the SPI4-encoded type I secretion system from Salmonella Typhimurium Protein Expression and Purification 172 2020 ), Art.Nr.: 105632 ISSN: 1046-5928 10.1016/j.pep.2020.105632 Download Marschall M. , Häge S. , Conrad M. , Alkhashrom S. , Kicuntod J. , Schweininger J. , Kriegel M. , Loesing J. , Tillmanns J. , Neipel F. , Eichler J. , Muller Y. , Sticht H. :Nuclear Egress Complexes of HCMV and Other Herpesviruses: Solving the Puzzle of Sequence Coevolution, Conserved Structures and Subfamily-Spanning Binding Properties Viruses 12 2020 )ISSN: 1999-4915 10.3390/v12060683 Download Muller Y. , Häge S. , Alkhashrom S. , Höllriegl T. , Weigert S. , Dolles S. , Hof K. , Walzer S. , Egerer-Sieber C. , Conrad M. , Holst S. , Lösing J. , Sonntag E. , Sticht H. , Eichler J. , Marschall M. , Marschall M. :High-resolution crystal structures of two prototypical β- And γ-herpesviral nuclear egress complexes unravel the determinants of subfamily specificity Journal of Biological Chemistry 295 2020 ), S. 3189-3201 ISSN: 0021-9258 10.1074/jbc.RA119.011546 Download
2019
Düthorn A. , Turan A. , Drassner C. , Muehl-Zurbes P. , Heilingloh C. , Steinkasserer A. , Grosche L. :siRNA Electroporation to Modulate Autophagy in Herpes Simplex Virus Type 1-Infected Monocyte-Derived Dendritic Cells Journal of Visualized Experiments 2019 )ISSN: 1940-087X 10.3791/60190 Download Gardill B. , Schmidt K. , Muller Y. :NewBG: A surrogate corticosteroid-binding globulin with an unprecedentedly high ligand release efficacy Journal of Structural Biology 207 2019 ), S. 169-182 ISSN: 1047-8477 10.1016/j.jsb.2019.05.006 Download Kirchweger P. , Weiler S. , Egerer-Sieber C. , Blasl AT. , Hoffmann S. , Schmidt C. , Sander N. , Merker D. , Gerlach R. , Hensel M. , Muller Y. :Structural and functional characterization of SiiA, an auxiliary protein from the SPI4-encoded type 1 secretion system from Salmonella enterica Molecular Microbiology 2019 )ISSN: 0950-382X 10.1111/mmi.14368 Download Schmitt C. , Bafna JA. , Schmid B. , Klingl S. , Baier S. , Hemmis B. , Wagner R. , Winterhalter M. , Voll L. :Manipulation of charge distribution in the arginine and glutamate clusters of the OmpG pore alters sugar specificity and ion selectivity Biochimica Et Biophysica Acta-Biomembranes 1861 2019 ), Art.Nr.: 183021 ISSN: 0005-2736 10.1016/j.bbamem.2019.07.009 Download
2018
Bartoschik T. , Galinec S. , Kleusch C. , Walkiewicz K. , Breitsprecher D. , Weigert S. , Muller Y. , You C. , Piehler J. , Vercruysse T. , Daelemans D. , Tschammer N. :Near-native, site-specific and purification-free protein labeling for quantitative protein interaction analysis by MicroScale Thermophoresis. Scientific Reports 8 2018 ), S. 4977 ISSN: 2045-2322 10.1038/s41598-018-23154-3 Download Leidner F. , Kurt YN. , Paulsen J. , Muller Y. , Schiffer C. :Hydration Structure and Dynamics of Inhibitor-Bound HIV-1 Protease. Journal of Chemical Theory and Computation 14 2018 ), S. 2784-2796 ISSN: 1549-9618 10.1021/acs.jctc.8b00097 Download Schmidt K. , Gardill B. , Kern A. , Kirchweger P. , Börsch M. , Muller Y. :Design of an allosterically modulated doxycycline and doxorubicin drug-binding protein. Proceedings of the National Academy of Sciences of the United States of America 2018 )ISSN: 0027-8424 10.1073/pnas.1716666115 Download Schmidt K. , Petersen J. , Munkert J. , Egerer-Sieber C. , Hornig M. , Muller Y. , Kreis W. :PRISEs (progesterone 5β-reductase and/or iridoid synthase-like 1,4-enone reductases): Catalytic and substrate promiscuity allows for realization of multiple pathways in plant metabolism. Phytochemistry 156 2018 ), S. 9-19 ISSN: 0031-9422 10.1016/j.phytochem.2018.08.012 Download
2017
Heilingloh C. , Klingl S. , Egerer-Sieber C. , Schmid B. , Weiler S. , Mühl-Zürbes P. , Hofmann J. , Stump J. , Sticht H. , Kummer M. , Steinkasserer A. , Muller Y. :Crystal Structure of the Extracellular Domain of the Human Dendritic Cell Surface Marker CD83 Journal of Molecular Biology 429 2017 ), S. 1227-1243 ISSN: 0022-2836 10.1016/j.jmb.2017.03.009 Download Marschall M. , Muller Y. , Diewald B. , Sticht H. , Milbradt J. :The human cytomegalovirus nuclear egress complex unites multiple functions: Recruitment of effectors, nuclear envelope rearrangement, and docking to nuclear capsids Reviews in Medical Virology 27 2017 ), Art.Nr.: e1934 ISSN: 1099-1654 10.1002/rmv.1934 Download Peters B. , Stein J. , Klingl S. , Sander N. , Sandmann A. , Taccardi N. , Sticht H. , Gerlach R. , Muller Y. , Hensel M. :Structural and functional dissection reveals distinct roles of Ca2+-binding sites in the giant adhesin SiiE of Salmonella enterica PLoS Pathogens 13 2017 ), Art.Nr.: e1006418 ISSN: 1553-7366 10.1371/journal.ppat.1006418 https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1006418 Download Peters B. , Stein J. , Klingl S. , Sander N. , Sandmann A. , Taccardi N. , Sticht H. , Gerlach RG. , Muller Y. , Hensel M. :Structural and functional dissection reveals distinct roles of Ca2+-binding sites in the giant adhesin SiiE of Salmonella enterica PLoS Pathogens 13 2017 ), Art.Nr.: e1006418 ISSN: 1553-7366 10.1371/journal.ppat.1006418 Download Schilling EM. , Scherer M. , Reuter N. , Schweininger J. , Muller Y. , Stamminger T. :The human cytomegalovirus IE1 protein antagonizes PML nuclear body-mediated intrinsic immunity via the inhibition of PML de novo SUMOylation Journal of Virology 91 2017 ), Art.Nr.: e02049-16 ISSN: 0022-538X 10.1128/JVI.02049-16 Download Schäfer W. , Eckart R. , Schmid B. , Cagkoeylue H. , Hof K. , Muller Y. , Amin B. , Lührmann A. :Nuclear trafficking of the anti-apoptotic Coxiella burnetii effector protein AnkG requires binding to p32 and Importin-alpha 1 Cellular Microbiology 19 2017 ), S. e12634- ISSN: 1462-5814 Download Sevvana M. , Hasselt K. , Grau F. , Burkovski A. , Muller Y. :Similarities in the structure of the transcriptional repressor AmtR in two different space groups suggest a model for the interaction with GlnK Acta Crystallographica Section:F Structural Biology Communications 73 2017 ), S. 146-151 ISSN: 2053-230X 10.1107/S2053230X17002485 Download
2016
Fillenberg S. , Frieß M. , Körner S. , Böckmann R. , Muller Y. :Crystal Structures of the Global Regulator DasR from Streptomyces coelicolor: Implications for the Allosteric Regulation of GntR/HutC Repressors. PLoS ONE 11 2016 ), S. e0157691 ISSN: 1932-6203 10.1371/journal.pone.0157691 Download Rudolph K. , Parthier C. , Egerer-Sieber C. , Geiger D. , Muller Y. , Kreis W. , Müller-Uri F. :Expression, crystallization and structure elucidation of γ-terpinene synthase from Thymus vulgaris Acta Crystallographica Section F: Structural Biology and Crystallization Communications 72 2016 ), S. 16-23 ISSN: 1744-3091 10.1107/S2053230X15023043 Download Schäfer W. , Eckart R. , Schmid B. , Cagköylü H. , Hof K. , Muller Y. , Amin B. , Lührmann A. :Nuclear trafficking of the anti-apoptotic Coxiella burnetii effector protein AnkG requires binding to p32 and Importin-α1 Cellular Microbiology 19 2016 )ISSN: 1462-5814 10.1111/cmi.12634 Download
2015
Fillenberg S. , Grau F. , Seidel G. , Muller Y. :Structural insight into operator dre-sites recognition and effector binding in the GntR/HutC transcription regulator NagR Nucleic Acids Research 43 2015 ), S. 1283-1296 ISSN: 0305-1048 10.1093/nar/gku1374 Download Klingl S. , Scherer M. , Stamminger T. , Muller Y. :Controlled crystal dehydration triggers a space-group switch and shapes the tertiary structure of cytomegalovirus immediate-early 1 (IE1) protein Acta Crystallographica Section D: Biological Crystallography 71 2015 ), S. 1493-1504 ISSN: 1399-0047 10.1107/S1399004715008792 Download Scherer M. , Otto V. , Stump J. , Klingl S. , Müller R. , Reuter N. , Muller Y. , Sticht H. , Stamminger T. :Characterization of recombinant human cytomegaloviruses encoding IE1 mutants L174P and 1-382 reveals that viral targeting of PML bodies perturbs both intrinsic and innate immune responses Journal of Virology 90 2015 ), S. 1190-1205 ISSN: 0022-538X 10.1128/JVI.01973-15 Download Tenconi E. , Urem M. , Świątek-Połatyńska MA. , Titgemeyer F. , Muller Y. , van Wezel G. , Rigali S. :Multiple allosteric effectors control the affinity of DasR for its target sites Biochemical and Biophysical Research Communications 464 2015 ), S. 324-329 ISSN: 0006-291X 10.1016/j.bbrc.2015.06.152 Download Walzer S. , Egerer-Sieber C. , Sticht H. , Sevvana M. , Hohl K. , Milbradt J. , Muller Y. , Marschall M. :Crystal structure of the human cytomegalovirus pUL50-pUL53 core nuclear egress complex provides insight into a unique assembly scaffold for virus-host protein interactions Journal of Biological Chemistry 290 2015 ), S. 27452-27458 ISSN: 0021-9258 10.1074/jbc.C115.686527 Download
2014
Eckart R. , Bisle S. , Schulze-Luehrmann J. , Wittmann I. , Jantsch J. , Schmid B. , Berens C. , Lührmann A. :Antiapoptotic activity of Coxiella burnetii effector protein AnkG is controlled by p32-dependent trafficking Infection and Immunity 82 2014 ), S. 2763-2771 ISSN: 0019-9567 10.1128/IAI.01204-13 Download Rudolph K. , Bauer P. , Schmid B. , Müller-Uri F. , Kreis W. :Truncation of N-terminal regions of Digitalis lanata progesterone 5β-reductase alters catalytic efficiency and substrate preference Biochimie 101 2014 ), S. 31-38 ISSN: 0300-9084 10.1016/j.biochi.2013.12.010 Download Scherer M. , Klingl S. , Sevvana M. , Otto V. , Schilling EM. , Stump J. , Müller R. , Reuter N. , Sticht H. , Muller Y. , Stamminger T. :Crystal structure of cytomegalovirus IE1 protein reveals targeting of TRIM family member PML via coiled-coil interactions PLoS Pathogens 10 2014 ), S. e1004512 ISSN: 1553-7366 10.1371/journal.ppat.1004512 Download Spindler N. , Diestel U. , Stump J. , Wiegers AK. , Winkler T. , Sticht H. , Mach M. , Muller Y. :Structural Basis for the Recognition of Human Cytomegalovirus Glycoprotein B by a Neutralizing Human Antibody PLoS Pathogens 10 2014 ), S. e1004377 ISSN: 1553-7366 10.1371/journal.ppat.1004377 Download Tegtmeyer N. , Lind J. , Schmid B. , Backert S. :Helicobacter pylori CagL Y58/E59 mutation turns-off type IV secretion-dependent delivery of CagA into host cells PLoS ONE 9 2014 ), Art.Nr.: e97782 ISSN: 1932-6203 10.1371/journal.pone.0097782 Download
2013
Diestel U. , Resch M. , Meinhardt K. , Weiler S. , Hellmann TV. , Mueller TD. , Nickel J. , Eichler J. , Muller Y. :Identification of a Novel TGF-β-Binding Site in the Zona Pellucida C-terminal (ZP-C) Domain of TGF-β-Receptor-3 (TGFR-3) PLoS ONE 8 2013 ), Art.Nr.: e67214 ISSN: 1932-6203 10.1371/journal.pone.0067214 Download Grießl M. , Schmid B. , Kaßler K. , Braunsmann C. , Ritter R. , Barlag B. , Stierhof YD. , Sturm KU. , Danzer CA. , Wagner C. , Schaeffer TE. , Sticht H. , Hensel M. , Muller Y. :Structural insight into the giant Ca²?-binding adhesin SiiE: implications for the adhesion of Salmonella enterica to polarized epithelial cells Structure 21 2013 ), S. 741-52 ISSN: 0969-2126 10.1016/j.str.2013.02.020 Download Muller Y. :Unexpected features in the Protein Data Bank entries 3qd1 and 4i8e: The structural description of the binding of the serine-rich repeat adhesin GspB to host cell carbohydrate receptor is not a solved issue Acta Crystallographica Section F: Structural Biology and Crystallization Communications 69 2013 ), S. 1071-1076 ISSN: 1744-3091 10.1107/S1744309113014383 Download Paulus K. , Schmid B. , Mahler V. , Sonnewald U. :Development of a yeast-based screening system for the identification of allergenic determinants of profilins Allergy 68 2013 ), S. 135-135 ISSN: 0105-4538 Download Spindler N. , Ruecker P. , Pötzsch S. , Diestel U. , Sticht H. , Martin-Parras L. , Winkler T. , Mach M. :Characterization of a discontinuous neutralizing epitope on glycoprotein B of human cytomegalovirus Journal of Virology 87 2013 ), S. 8927-39 ISSN: 0022-538X 10.1128/JVI.00434-13 Download
2012
Gardill B. , Vogl MR. , Lin HY. , Hammond GL. , Muller Y. :Corticosteroid-Binding Globulin: Structure-Function Implications from Species Differences PLoS ONE 7 2012 ), Art.Nr.: e52759 ISSN: 1932-6203 10.1371/journal.pone.0052759 Download Grießl M. , Jungkunz I. , Sonnewald U. , Muller Y. :Purification, crystallization and preliminary X-ray diffraction analysis of the Hsp40 protein CPIP1 from Nicotiana tabacum Acta Crystallographica Section F: Structural Biology and Crystallization Communications 68 2012 ), S. 236-239 ISSN: 1744-3091 10.1107/S1744309111055928 Download Hahn A. , Kaufmann JK. , Wies E. , Naschberger E. , Panteleev-Ivlev J. , Schmidt K. , Holzer A. , Schmidt M. , Chen J. , Koenig S. , Enßer A. , Myoung J. , Brockmeyer NH. , Stürzl M. , Fleckenstein B. , Neipel F. :The ephrin receptor tyrosine kinase A2 is a cellular receptor for Kaposi's sarcoma-associated herpesvirus Nature Medicine 18 2012 ), S. 961-966 ISSN: 1078-8956 10.1038/nm.2805 Download Milbradt J. , Auerochs S. , Sevvana M. , Muller Y. , Sticht H. , Marschall M. :Specific residues of a conserved domain in the N terminus of the human cytomegalovirus pUL50 protein determine its intranuclear interaction with pUL53 Journal of Biological Chemistry 287 2012 ), S. 24004-16 ISSN: 0021-9258 10.1074/jbc.M111.331207 Download Paulus K. , Schmid B. , Zajic D. , Schaefer A. , Mahler V. , Sonnewald U. :Hypoallergenic profilin - A new way to identify allergenic determinants Febs Journal 279 2012 ), S. 2727-2736 ISSN: 1742-464X 10.1111/j.1742-4658.2012.08656.x Download
2010
2009
Hasselt K, Sevvana M, Burkovski A, Muller, Y:Crystallization and preliminary analysis of selenomethionine-labelled AmtR from Corynebacterium glutamicum Acta Crystallographica Section F: Structural Biology and Crystallization Communications 65 2009 ), S. 1123-1127 ISSN: 1744-3091 10.1107/S174430910903663X Download
Herl V. , Fischer G. , Reva VA. , Stiebritz M. , Muller Y. , Müller-Uri F. , Kreis W. :The VEP1 gene (At4g24220) encodes a short-chain dehydrogenase/reductase with 3-oxo-Δ4,5-steroid 5β-reductase activity in Arabidopsis thaliana L. Biochimie 91 2009 ), S. 517-525 ISSN: 0300-9084 10.1016/j.biochi.2008.12.005 Download Klieber MA. , Scholz O. , Lochner S. , Gmeiner P. , Hillen W. , Muller Y. :Structural origins for selectivity and specificity in an engineered bacterial repressor-inducer pair Febs Journal 276 2009 ), S. 5610-5621 ISSN: 1742-464X 10.1111/j.1742-4658.2009.07254.x Download
2008
Resch M. , Striegl H. , Henssler E. , Sevvana M. , Egerer-Sieber C. , Schiltz E. , Hillen W. , Muller Y. :A protein functional leap: how a single mutation reverses the function of the transcription regulator TetR Nucleic Acids Research 36 2008 ), S. 4390-4401 ISSN: 0305-1048 10.1093/nar/gkn400 Download Thorn A. , Egerer-Sieber C. , Jäger C. , Herl V. , Müller-Uri F. , Kreis W. , Muller Y. :The crystal structure of progesterone 5beta-reductase from Digitalis lanata defines a novel class of short-chain dehydrogenases/reductases Journal of Biological Chemistry 283 2008 ), S. 17260-17269 ISSN: 0021-9258 10.1074/jbc.M706185200 Download
2007
2006
