Publications

2021

• Alkhashrom S., Kicuntod J., Häge S., Schweininger J., Muller Y., Lischka P., Marschall M., Eichler J.:
  Exploring the Human Cytomegalovirus Core Nuclear Egress Complex as a Novel Antiviral Target: A New Type of Small Molecule Inhibitors
  In: Viruses 13 (2021)
  ISSN: 1999-4915
  DOI: 10.3390/v13030471
  BibTeX: Download
• Grau F., Burkovski A., Muller Y.:
  Crystal structures of adenylylated and unadenylylated PII protein GlnK from Corynebacterium glutamicum
  In: Acta Crystallographica Section D : Structural Biology 77 (2021), S. 325-335
  ISSN: 2059-7983
  DOI: 10.1107/S2059798321000735
  BibTeX: Download

2020

• Grau F., Jaeger J., Groher F., Suess B., Muller Y.:
  The complex formed between a synthetic RNA aptamer and the transcription repressor TetR is a structural and functional twin of the operator DNA-TetR regulator complex
  In: Nucleic Acids Research 48 (2020), S. 3366-3378
  ISSN: 0305-1048
  DOI: 10.1093/nar/gkaa083
  BibTeX: Download
• Grosche L., Knippertz I., König C., Royzman D., Wild A., Zinser E., Sticht H., Muller Y., Steinkasserer A., Lechmann M.:
  The CD83 Molecule – An Important Immune Checkpoint
  In: Frontiers in Immunology 11 (2020), Art.Nr.: 721
  ISSN: 1664-3224
  DOI: 10.3389/fimmu.2020.00721
  BibTeX: Download
• Klingl S., Kordes S., Schmid B., Gerlach R., Hensel M., Muller Y.:
  Recombinant protein production and purification of SiiD, SiiE and SiiF - Components of the SPI4-encoded type I secretion system from Salmonella Typhimurium
  In: Protein Expression and Purification 172 (2020), Art.Nr.: 105632
  ISSN: 1046-5928
  DOI: 10.1016/j.pep.2020.105632
  BibTeX: Download
• Marschall M., Häge S., Conrad M., Alkhashrom S., Kicuntod J., Schweininger J., Kriegel M., Loesing J., Tillmanns J., Neipel F., Eichler J., Muller Y., Sticht H.:
  Nuclear Egress Complexes of HCMV and Other Herpesviruses: Solving the Puzzle of Sequence Coevolution, Conserved Structures and Subfamily-Spanning Binding Properties
  In: Viruses 12 (2020)
  ISSN: 1999-4915
  DOI: 10.3390/v12060683
  BibTeX: Download
• Muller Y., Häge S., Alkhashrom S., Höllriegl T., Weigert S., Dolles S., Hof K., Walzer S., Egerer-Sieber C., Conrad M., Holst S., Lösing J., Sonntag E., Sticht H., Eichler J., Marschall M., Marschall M.:
  High-resolution crystal structures of two prototypical β- And γ-herpesviral nuclear egress complexes unravel the determinants of subfamily specificity
  In: Journal of Biological Chemistry 295 (2020), S. 3189-3201
  ISSN: 0021-9258
  DOI: 10.1074/jbc.RA119.011546
  BibTeX: Download

2019

• Düthorn A., Turan A., Drassner C., Muehl-Zurbes P., Heilingloh C., Steinkasserer A., Grosche L.:
  siRNA Electroporation to Modulate Autophagy in Herpes Simplex Virus Type 1-Infected Monocyte-Derived Dendritic Cells
  In: Journal of Visualized Experiments (2019)
  ISSN: 1940-087X
  DOI: 10.3791/60190
  BibTeX: Download
• Gardill B., Schmidt K., Muller Y.:
  NewBG: A surrogate corticosteroid-binding globulin with an unprecedentedly high ligand release efficacy
  In: Journal of Structural Biology 207 (2019), S. 169-182
  ISSN: 1047-8477
  DOI: 10.1016/j.jsb.2019.05.006
  BibTeX: Download
• Kirchweger P., Weiler S., Egerer-Sieber C., Blasl AT., Hoffmann S., Schmidt C., Sander N., Merker D., Gerlach R., Hensel M., Muller Y.:
  Structural and functional characterization of SiiA, an auxiliary protein from the SPI4-encoded type 1 secretion system from Salmonella enterica
  In: Molecular Microbiology (2019)
  ISSN: 0950-382X
  DOI: 10.1111/mmi.14368
  BibTeX: Download
• Schmitt C., Bafna JA., Schmid B., Klingl S., Baier S., Hemmis B., Wagner R., Winterhalter M., Voll L.:
  Manipulation of charge distribution in the arginine and glutamate clusters of the OmpG pore alters sugar specificity and ion selectivity
  In: Biochimica Et Biophysica Acta-Biomembranes 1861 (2019), Art.Nr.: 183021
  ISSN: 0005-2736
  DOI: 10.1016/j.bbamem.2019.07.009
  BibTeX: Download

2018

• Bartoschik T., Galinec S., Kleusch C., Walkiewicz K., Breitsprecher D., Weigert S., Muller Y., You C., Piehler J., Vercruysse T., Daelemans D., Tschammer N.:
  Near-native, site-specific and purification-free protein labeling for quantitative protein interaction analysis by MicroScale Thermophoresis.
  In: Scientific Reports 8 (2018), S. 4977
  ISSN: 2045-2322
  DOI: 10.1038/s41598-018-23154-3
  BibTeX: Download
• Leidner F., Kurt YN., Paulsen J., Muller Y., Schiffer C.:
  Hydration Structure and Dynamics of Inhibitor-Bound HIV-1 Protease.
  In: Journal of Chemical Theory and Computation 14 (2018), S. 2784-2796
  ISSN: 1549-9618
  DOI: 10.1021/acs.jctc.8b00097
  BibTeX: Download
• Schmidt K., Gardill B., Kern A., Kirchweger P., Börsch M., Muller Y.:
  Design of an allosterically modulated doxycycline and doxorubicin drug-binding protein.
  In: Proceedings of the National Academy of Sciences of the United States of America (2018)
  ISSN: 0027-8424
  DOI: 10.1073/pnas.1716666115
  BibTeX: Download
• Schmidt K., Petersen J., Munkert J., Egerer-Sieber C., Hornig M., Muller Y., Kreis W.:
  PRISEs (progesterone 5β-reductase and/or iridoid synthase-like 1,4-enone reductases): Catalytic and substrate promiscuity allows for realization of multiple pathways in plant metabolism.
  In: Phytochemistry 156 (2018), S. 9-19
  ISSN: 0031-9422
  DOI: 10.1016/j.phytochem.2018.08.012
  BibTeX: Download

2017

• Heilingloh C., Klingl S., Egerer-Sieber C., Schmid B., Weiler S., Mühl-Zürbes P., Hofmann J., Stump J., Sticht H., Kummer M., Steinkasserer A., Muller Y.:
  Crystal Structure of the Extracellular Domain of the Human Dendritic Cell Surface Marker CD83
  In: Journal of Molecular Biology 429 (2017), S. 1227-1243
  ISSN: 0022-2836
  DOI: 10.1016/j.jmb.2017.03.009
  BibTeX: Download
• Marschall M., Muller Y., Diewald B., Sticht H., Milbradt J.:
  The human cytomegalovirus nuclear egress complex unites multiple functions: Recruitment of effectors, nuclear envelope rearrangement, and docking to nuclear capsids
  In: Reviews in Medical Virology 27 (2017), Art.Nr.: e1934
  ISSN: 1099-1654
  DOI: 10.1002/rmv.1934
  BibTeX: Download
• Peters B., Stein J., Klingl S., Sander N., Sandmann A., Taccardi N., Sticht H., Gerlach R., Muller Y., Hensel M.:
  Structural and functional dissection reveals distinct roles of Ca2+-binding sites in the giant adhesin SiiE of Salmonella enterica
  In: PLoS Pathogens 13 (2017), Art.Nr.: e1006418
  ISSN: 1553-7366
  DOI: 10.1371/journal.ppat.1006418
  URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1006418
  BibTeX: Download
• Peters B., Stein J., Klingl S., Sander N., Sandmann A., Taccardi N., Sticht H., Gerlach RG., Muller Y., Hensel M.:
  Structural and functional dissection reveals distinct roles of Ca2+-binding sites in the giant adhesin SiiE of Salmonella enterica
  In: PLoS Pathogens 13 (2017), Art.Nr.: e1006418
  ISSN: 1553-7366
  DOI: 10.1371/journal.ppat.1006418
  BibTeX: Download
• Schilling EM., Scherer M., Reuter N., Schweininger J., Muller Y., Stamminger T.:
  The human cytomegalovirus IE1 protein antagonizes PML nuclear body-mediated intrinsic immunity via the inhibition of PML de novo SUMOylation
  In: Journal of Virology 91 (2017), Art.Nr.: e02049-16
  ISSN: 0022-538X
  DOI: 10.1128/JVI.02049-16
  BibTeX: Download
• Schäfer W., Eckart R., Schmid B., Cagkoeylue H., Hof K., Muller Y., Amin B., Lührmann A.:
  Nuclear trafficking of the anti-apoptotic Coxiella burnetii effector protein AnkG requires binding to p32 and Importin-alpha 1
  In: Cellular Microbiology 19 (2017), S. e12634-
  ISSN: 1462-5814
  BibTeX: Download
• Sevvana M., Hasselt K., Grau F., Burkovski A., Muller Y.:
  Similarities in the structure of the transcriptional repressor AmtR in two different space groups suggest a model for the interaction with GlnK
  In: Acta Crystallographica Section:F Structural Biology Communications 73 (2017), S. 146-151
  ISSN: 2053-230X
  DOI: 10.1107/S2053230X17002485
  BibTeX: Download

2016

• Fillenberg S., Frieß M., Körner S., Böckmann R., Muller Y.:
  Crystal Structures of the Global Regulator DasR from Streptomyces coelicolor: Implications for the Allosteric Regulation of GntR/HutC Repressors.
  In: PLoS ONE 11 (2016), S. e0157691
  ISSN: 1932-6203
  DOI: 10.1371/journal.pone.0157691
  BibTeX: Download
• Rudolph K., Parthier C., Egerer-Sieber C., Geiger D., Muller Y., Kreis W., Müller-Uri F.:
  Expression, crystallization and structure elucidation of γ-terpinene synthase from Thymus vulgaris
  In: Acta Crystallographica Section F: Structural Biology and Crystallization Communications 72 (2016), S. 16-23
  ISSN: 1744-3091
  DOI: 10.1107/S2053230X15023043
  BibTeX: Download
• Schäfer W., Eckart R., Schmid B., Cagköylü H., Hof K., Muller Y., Amin B., Lührmann A.:
  Nuclear trafficking of the anti-apoptotic Coxiella burnetii effector protein AnkG requires binding to p32 and Importin-α1
  In: Cellular Microbiology 19 (2016)
  ISSN: 1462-5814
  DOI: 10.1111/cmi.12634
  BibTeX: Download

2015

• Fillenberg S., Grau F., Seidel G., Muller Y.:
  Structural insight into operator dre-sites recognition and effector binding in the GntR/HutC transcription regulator NagR
  In: Nucleic Acids Research 43 (2015), S. 1283-1296
  ISSN: 0305-1048
  DOI: 10.1093/nar/gku1374
  BibTeX: Download
• Klingl S., Scherer M., Stamminger T., Muller Y.:
  Controlled crystal dehydration triggers a space-group switch and shapes the tertiary structure of cytomegalovirus immediate-early 1 (IE1) protein
  In: Acta Crystallographica Section D: Biological Crystallography 71 (2015), S. 1493-1504
  ISSN: 1399-0047
  DOI: 10.1107/S1399004715008792
  BibTeX: Download
• Scherer M., Otto V., Stump J., Klingl S., Müller R., Reuter N., Muller Y., Sticht H., Stamminger T.:
  Characterization of recombinant human cytomegaloviruses encoding IE1 mutants L174P and 1-382 reveals that viral targeting of PML bodies perturbs both intrinsic and innate immune responses
  In: Journal of Virology 90 (2015), S. 1190-1205
  ISSN: 0022-538X
  DOI: 10.1128/JVI.01973-15
  BibTeX: Download
• Tenconi E., Urem M., Świątek-Połatyńska MA., Titgemeyer F., Muller Y., van Wezel G., Rigali S.:
  Multiple allosteric effectors control the affinity of DasR for its target sites
  In: Biochemical and Biophysical Research Communications 464 (2015), S. 324-329
  ISSN: 0006-291X
  DOI: 10.1016/j.bbrc.2015.06.152
  BibTeX: Download
• Walzer S., Egerer-Sieber C., Sticht H., Sevvana M., Hohl K., Milbradt J., Muller Y., Marschall M.:
  Crystal structure of the human cytomegalovirus pUL50-pUL53 core nuclear egress complex provides insight into a unique assembly scaffold for virus-host protein interactions
  In: Journal of Biological Chemistry 290 (2015), S. 27452-27458
  ISSN: 0021-9258
  DOI: 10.1074/jbc.C115.686527
  BibTeX: Download

2014

• Eckart R., Bisle S., Schulze-Luehrmann J., Wittmann I., Jantsch J., Schmid B., Berens C., Lührmann A.:
  Antiapoptotic activity of Coxiella burnetii effector protein AnkG is controlled by p32-dependent trafficking
  In: Infection and Immunity 82 (2014), S. 2763-2771
  ISSN: 0019-9567
  DOI: 10.1128/IAI.01204-13
  BibTeX: Download
• Rudolph K., Bauer P., Schmid B., Müller-Uri F., Kreis W.:
  Truncation of N-terminal regions of Digitalis lanata progesterone 5β-reductase alters catalytic efficiency and substrate preference
  In: Biochimie 101 (2014), S. 31-38
  ISSN: 0300-9084
  DOI: 10.1016/j.biochi.2013.12.010
  BibTeX: Download
• Scherer M., Klingl S., Sevvana M., Otto V., Schilling EM., Stump J., Müller R., Reuter N., Sticht H., Muller Y., Stamminger T.:
  Crystal structure of cytomegalovirus IE1 protein reveals targeting of TRIM family member PML via coiled-coil interactions
  In: PLoS Pathogens 10 (2014), S. e1004512
  ISSN: 1553-7366
  DOI: 10.1371/journal.ppat.1004512
  BibTeX: Download
• Spindler N., Diestel U., Stump J., Wiegers AK., Winkler T., Sticht H., Mach M., Muller Y.:
  Structural Basis for the Recognition of Human Cytomegalovirus Glycoprotein B by a Neutralizing Human Antibody
  In: PLoS Pathogens 10 (2014), S. e1004377
  ISSN: 1553-7366
  DOI: 10.1371/journal.ppat.1004377
  BibTeX: Download
• Tegtmeyer N., Lind J., Schmid B., Backert S.:
  Helicobacter pylori CagL Y58/E59 mutation turns-off type IV secretion-dependent delivery of CagA into host cells
  In: PLoS ONE 9 (2014), Art.Nr.: e97782
  ISSN: 1932-6203
  DOI: 10.1371/journal.pone.0097782
  BibTeX: Download

2013

• Diestel U., Resch M., Meinhardt K., Weiler S., Hellmann TV., Mueller TD., Nickel J., Eichler J., Muller Y.:
  Identification of a Novel TGF-β-Binding Site in the Zona Pellucida C-terminal (ZP-C) Domain of TGF-β-Receptor-3 (TGFR-3)
  In: PLoS ONE 8 (2013), Art.Nr.: e67214
  ISSN: 1932-6203
  DOI: 10.1371/journal.pone.0067214
  BibTeX: Download
• Grießl M., Schmid B., Kaßler K., Braunsmann C., Ritter R., Barlag B., Stierhof YD., Sturm KU., Danzer CA., Wagner C., Schaeffer TE., Sticht H., Hensel M., Muller Y.:
  Structural insight into the giant Ca²?-binding adhesin SiiE: implications for the adhesion of Salmonella enterica to polarized epithelial cells
  In: Structure 21 (2013), S. 741-52
  ISSN: 0969-2126
  DOI: 10.1016/j.str.2013.02.020
  BibTeX: Download
• Muller Y.:
  Unexpected features in the Protein Data Bank entries 3qd1 and 4i8e: The structural description of the binding of the serine-rich repeat adhesin GspB to host cell carbohydrate receptor is not a solved issue
  In: Acta Crystallographica Section F: Structural Biology and Crystallization Communications 69 (2013), S. 1071-1076
  ISSN: 1744-3091
  DOI: 10.1107/S1744309113014383
  BibTeX: Download
• Paulus K., Schmid B., Mahler V., Sonnewald U.:
  Development of a yeast-based screening system for the identification of allergenic determinants of profilins
  In: Allergy 68 (2013), S. 135-135
  ISSN: 0105-4538
  BibTeX: Download
• Spindler N., Ruecker P., Pötzsch S., Diestel U., Sticht H., Martin-Parras L., Winkler T., Mach M.:
  Characterization of a discontinuous neutralizing epitope on glycoprotein B of human cytomegalovirus
  In: Journal of Virology 87 (2013), S. 8927-39
  ISSN: 0022-538X
  DOI: 10.1128/JVI.00434-13
  BibTeX: Download

2012

• Gardill B., Vogl MR., Lin HY., Hammond GL., Muller Y.:
  Corticosteroid-Binding Globulin: Structure-Function Implications from Species Differences
  In: PLoS ONE 7 (2012), Art.Nr.: e52759
  ISSN: 1932-6203
  DOI: 10.1371/journal.pone.0052759
  BibTeX: Download
• Grießl M., Jungkunz I., Sonnewald U., Muller Y.:
  Purification, crystallization and preliminary X-ray diffraction analysis of the Hsp40 protein CPIP1 from Nicotiana tabacum
  In: Acta Crystallographica Section F: Structural Biology and Crystallization Communications 68 (2012), S. 236-239
  ISSN: 1744-3091
  DOI: 10.1107/S1744309111055928
  BibTeX: Download
• Hahn A., Kaufmann JK., Wies E., Naschberger E., Panteleev-Ivlev J., Schmidt K., Holzer A., Schmidt M., Chen J., Koenig S., Enßer A., Myoung J., Brockmeyer NH., Stürzl M., Fleckenstein B., Neipel F.:
  The ephrin receptor tyrosine kinase A2 is a cellular receptor for Kaposi's sarcoma-associated herpesvirus
  In: Nature Medicine 18 (2012), S. 961-966
  ISSN: 1078-8956
  DOI: 10.1038/nm.2805
  BibTeX: Download
• Milbradt J., Auerochs S., Sevvana M., Muller Y., Sticht H., Marschall M.:
  Specific residues of a conserved domain in the N terminus of the human cytomegalovirus pUL50 protein determine its intranuclear interaction with pUL53
  In: Journal of Biological Chemistry 287 (2012), S. 24004-16
  ISSN: 0021-9258
  DOI: 10.1074/jbc.M111.331207
  BibTeX: Download
• Paulus K., Schmid B., Zajic D., Schaefer A., Mahler V., Sonnewald U.:
  Hypoallergenic profilin - A new way to identify allergenic determinants
  In: Febs Journal 279 (2012), S. 2727-2736
  ISSN: 1742-464X
  DOI: 10.1111/j.1742-4658.2012.08656.x
  BibTeX: Download

2010

• Bauer P., Munkert J., Brydziun M., Burda E., Müller-Uri F., Gröger H., Muller Y., Kreis W.:
  Highly conserved progesterone 5β-reductase (P5βR) genes, from 5β-cardenolide-free and 5β-cardenolide-producing angiosperms.
  In: Phytochemistry 71 (2010), S. 1495-1505
  ISSN: 0031-9422
  DOI: 10.1016/j.phytochem.2010.06.004
  BibTeX: Download

2009

• Hasselt K, Sevvana M, Burkovski A, Muller, Y:
  Crystallization and preliminary analysis of selenomethionine-labelled AmtR from Corynebacterium glutamicum
  In: Acta Crystallographica Section F: Structural Biology and Crystallization Communications 65 (2009), S. 1123-1127
  ISSN: 1744-3091
  DOI: 10.1107/S174430910903663X
  BibTeX: Download
• Herl V., Fischer G., Reva VA., Stiebritz M., Muller Y., Müller-Uri F., Kreis W.:
  The VEP1 gene (At4g24220) encodes a short-chain dehydrogenase/reductase with 3-oxo-Δ4,5-steroid 5β-reductase activity in Arabidopsis thaliana L.
  In: Biochimie 91 (2009), S. 517-525
  ISSN: 0300-9084
  DOI: 10.1016/j.biochi.2008.12.005
  BibTeX: Download
• Klieber MA., Scholz O., Lochner S., Gmeiner P., Hillen W., Muller Y.:
  Structural origins for selectivity and specificity in an engineered bacterial repressor-inducer pair
  In: Febs Journal 276 (2009), S. 5610-5621
  ISSN: 1742-464X
  DOI: 10.1111/j.1742-4658.2009.07254.x
  BibTeX: Download

2008

• Resch M., Striegl H., Henssler E., Sevvana M., Egerer-Sieber C., Schiltz E., Hillen W., Muller Y.:
  A protein functional leap: how a single mutation reverses the function of the transcription regulator TetR
  In: Nucleic Acids Research 36 (2008), S. 4390-4401
  ISSN: 0305-1048
  DOI: 10.1093/nar/gkn400
  BibTeX: Download
• Thorn A., Egerer-Sieber C., Jäger C., Herl V., Müller-Uri F., Kreis W., Muller Y.:
  The crystal structure of progesterone 5beta-reductase from Digitalis lanata defines a novel class of short-chain dehydrogenases/reductases
  In: Journal of Biological Chemistry 283 (2008), S. 17260-17269
  ISSN: 0021-9258
  DOI: 10.1074/jbc.M706185200
  BibTeX: Download

2007

• Pimentel-Schmitt EF., Thomae AW., Amon J., Klieber M., Roth HM., Muller Y., Jahreis K., Burkovski A., Titgemeyer F.:
  A glucose kinase from Mycobacterium smegmatis
  In: Journal of Molecular Microbiology and Biotechnology 12 (2007), S. 75-81
  ISSN: 1464-1801
  DOI: 10.1159/000096462
  BibTeX: Download

2006

• Egerer-Sieber C., Herl V., Müller-Uri F., Kreis W., Muller Y.:
  Crystallization and preliminary crystallographic analysis of selenomethoionine-labelled progesterone 5β-reductase from Digitalis lanata Ehrh.
  In: Acta Crystallographica Section F: Structural Biology and Crystallization Communications F62 (2006), S. 186-188
  ISSN: 1744-3091
  DOI: 10.1107/S1744309106001916
  BibTeX: Download
• Stiebritz M., Muller Y.:
  MUMBO: a protein-design approach to crystallographic model building and refinement.
  In: Acta Crystallographica Section D: Biological Crystallography 62 (2006), S. 648-658
  ISSN: 0907-4449
  DOI: 10.1107/S0907444906013333
  BibTeX: Download