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Probing protein architecture / protein design


Current advances in computational protein design enable the de novo design of proteins with novel properties. We have implemented established protein packing algorithms in the computer program MUMBO and are using these algorithms to transform homodimeric bacterial repressor into a chain-specific heterodimers, redesigning the specificity of enzymes and transferring ligand-binding sites between different protein scaffolds. The program MUMBO is freely available to academic users upon request.