De novo structure determination using X-ray crystallography

Our research effort is driven by the central question on how the three-dimensional structure of a biological macromolecule enables its biological function. Thus, we aim at understanding the nature of the allosteric behavior of bacterial transcription factors from the TetR and GntR/HutC family. As part of a larger collaborative effort we study host pathogen infection mechanisms in particular related to herpes viral and salmonella infections.